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Was (wer) ist Koplik"s spots - definition
![Cycle Deſign (Cycle Design) in [[Berlin]], 2002](https://commons.wikimedia.org/wiki/Special:FilePath/CycleDesign Kopie.jpg?width=200 "Cycle Deſign (Cycle Design) in [[Berlin]], 2002")
!["Miss Austen's"—an example of a handwritten long s in a letter from [[Charlotte Brontë]] to G. H. Lewes, 12 January 1848](https://commons.wikimedia.org/wiki/Special:FilePath/Example of handwritten ſ in a letter from Charlotte Brontë.jpg?width=200 "\"Miss Austen's\"—an example of a handwritten long s in a letter from [[Charlotte Brontë]] to G. H. Lewes, 12 January 1848")
![[[Wayside cross]] near [[Hohenfurch]], Germany, erected 1953, showing the long s in Roman typeface](https://commons.wikimedia.org/wiki/Special:FilePath/Flurkreuz bei Hohenfurch (errichtet 1953).jpg?width=200 "[[Wayside cross]] near [[Hohenfurch]], Germany, erected 1953, showing the long s in Roman typeface")
![ligature]] and a nub on the long s](https://commons.wikimedia.org/wiki/Special:FilePath/Milton paradise.jpg?width=200 "ligature]] and a nub on the long s")
.jpg?width=200 "Wasser-Aufsehers-Gattin}} (\"water attendant's wife\") containing a long s adjacent to an ''f''")
![German handwriting ([[Bastarda]]), 1496, showing long and round s (as well as an [[r rotunda]]) in "priesters"](https://commons.wikimedia.org/wiki/Special:FilePath/Schwäbische Bastarda 1496 Schriftprobe Priesters Tochter.png?width=200 "German handwriting ([[Bastarda]]), 1496, showing long and round s (as well as an [[r rotunda]]) in \"priesters\"")
Wikipedia
Koplik's spots (also Koplik's sign) are a prodromic viral enanthem of measles manifesting two to three days before the measles rash itself. They are characterized as clustered, white lesions on the buccal mucosa (opposite the lower 1st & 2nd molars) and are pathognomonic for measles. The textbook description of Koplik spots is ulcerated mucosal lesions marked by necrosis, neutrophilic exudate, and neovascularization. They are described as appearing like "grains of salt on a reddish background", and often fade as the maculopapular rash develops. As well as their diagnostic significance they are important in the control of outbreaks. Their appearance, in context of a diagnosed case, before they reach maximum infectivity, permits isolation of the contacts and greatly aids control of this highly infectious disease.
Nobel laureate John F. Enders and Thomas Peebles, who first isolated the measles virus, were careful to collect their samples from patients showing Koplik's spots.
